紋狀體多巴胺信號(hào)反映小鼠感知到的線索-行動(dòng)-結(jié)果關(guān)聯(lián)
2024.02.18德國(guó)慕尼黑工業(yè)大學(xué)Simon N. Jacob課題組發(fā)現(xiàn)，紋狀體多巴胺信號(hào)反映小鼠感知到的線索-行動(dòng)-結(jié)果關(guān)聯(lián)。相關(guān)論文于2024年1月30日在線發(fā)表于國(guó)際學(xué)術(shù)期刊《自然—神經(jīng)科學(xué)》。
研究人員對(duì)雄性小鼠的紋狀體進(jìn)行了光纖光度多巴胺測(cè)量，當(dāng)時(shí)它們正在根據(jù)隱含的和不斷變化的任務(wù)規(guī)則學(xué)習(xí)線索-行動(dòng)-結(jié)果關(guān)聯(lián)。行為和多巴胺數(shù)據(jù)的強(qiáng)化學(xué)習(xí)模型表明，規(guī)則的改變會(huì)導(dǎo)致所學(xué)線索-行動(dòng)-結(jié)果關(guān)聯(lián)的調(diào)整。規(guī)則改變后，小鼠會(huì)摒棄已學(xué)過(guò)的關(guān)聯(lián)，并重新設(shè)定結(jié)果預(yù)期。線索和結(jié)果觸發(fā)的多巴胺信號(hào)變得不耦合，并依賴于所采用的行為策略。隨著小鼠學(xué)會(huì)新的聯(lián)想，線索和結(jié)果觸發(fā)的多巴胺信號(hào)與任務(wù)表現(xiàn)之間的耦合重新出現(xiàn)。
這些研究結(jié)果表明，多巴胺能獎(jiǎng)賞預(yù)測(cè)錯(cuò)誤反映了行為主體感知到的控制位置。
據(jù)介紹，紋狀體多巴胺通過(guò)充當(dāng)教學(xué)信號(hào)驅(qū)動(dòng)聯(lián)想學(xué)習(xí)。許多工作都集中在簡(jiǎn)單的學(xué)習(xí)范式上，包括巴甫洛夫?qū)W習(xí)和工具學(xué)習(xí)。然而，高級(jí)認(rèn)知要求動(dòng)物對(duì)其環(huán)境產(chǎn)生內(nèi)部概念，將感官刺激、行動(dòng)和結(jié)果靈活地聯(lián)系起來(lái)。
附：英文原文
Title: Striatal dopamine signals reflect perceived cue–action–outcome associations in mice
Author: Bernklau, Tobias W., Righetti, Beatrice, Mehrke, Leonie S., Jacob, Simon N.
Issue&Volume: 2024-01-30
Abstract: Striatal dopamine drives associative learning by acting as a teaching signal. Much work has focused on simple learning paradigms, including Pavlovian and instrumental learning. However, higher cognition requires that animals generate internal concepts of their environment, where sensory stimuli, actions and outcomes become flexibly associated. Here, we performed fiber photometry dopamine measurements across the striatum of male mice as they learned cue–action–outcome associations based on implicit and changing task rules. Reinforcement learning models of the behavioral and dopamine data showed that rule changes lead to adjustments of learned cue–action–outcome associations. After rule changes, mice discarded learned associations and reset outcome expectations. Cue- and outcome-triggered dopamine signals became uncoupled and dependent on the adopted behavioral strategy. As mice learned the new association, coupling between cue- and outcome-triggered dopamine signals and task performance re-emerged. Our results suggest that dopaminergic reward prediction errors reflect an agent’s perceived locus of control.
DOI: 10.1038/s41593-023-01567-2
Source: https://www.nature.com/articles/s41593-023-01567-2
期刊信息
Nature Neuroscience：《自然—神經(jīng)科學(xué)》，創(chuàng)刊于1998年。隸屬于施普林格·自然出版集團(tuán)，IF：28.771
官方網(wǎng)址：https://www.nature.com/neuro
